Gator1 Complex Protein Depdc5 (DEPDC5) Reagents

GATOR1 complex protein DEPDC5

As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.

Epilepsy, familial focal, with variable foci 1 (FFEVF1)

Cytoplasm, cytosol. Cytoplasm, perinuclear region. Lysosome membrane.

IML1 family

Expressed in developing and adult brain.

DEP domain containing 5; DEP domain-containing protein 5; DEP.5; DEPD5_HUMAN; DEPDC5; FFEVF; KIAA0645