Sh3 And Px Domain-Containing Protein 2B (SH3PXD2B) Reagents

SH3 and PX domain-containing protein 2B

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.

Frank-Ter Haar syndrome (FTHS)

Cytoplasm. Cell projection, podosome.

SH3PXD2 family

Expressed in fibroblasts.

SH3PXD2B; FAD49; KIAA1295; TKS4; SH3 and PX domain-containing protein 2B; Adapter protein HOFI; Factor for adipocyte differentiation 49; Tyrosine kinase substrate with four SH3 domains