Amino acids 1-297 form the expressed segment for recombinant Human CDK1. This CDK1 protein is expected to have a theoretical molecular weight of 38.1 kDa. Expression of this CDK1 protein is conducted in e.coli. The N-terminal 6xHis tag was smoothly integrated into the coding gene of CDK1, which enables a simple process of detecting and purifying the CDK1 recombinant protein in the following steps.Cyclin-dependent kinase 1 (CDK1) is a pivotal protein kinase that governs the progression of the cell cycle, particularly during the transition from the G2 to M phase. Operating in concert with its regulatory partner, cyclin B, CDK1 orchestrates key cellular events such as nuclear envelope breakdown, chromosome condensation, and spindle assembly, crucial for successful cell division. The precise regulation of CDK1 activity is imperative for maintaining proper cell cycle dynamics. In the G1 phase, CDK1 remains inactive, and its activation is contingent on cyclin B binding as cells advance through the cell cycle. Dysregulation of CDK1 has been implicated in various diseases, notably cancer, underscoring its significance as a therapeutic target. Researchers are exploring CDK1 inhibitors for their potential to disrupt aberrant cell cycle progression, shedding light on novel strategies for cancer treatment.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[4665],"class_list":["post-109748","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-cdk1","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n