The expression region of this recombinant Human ACLY covers amino acids 4-265. The calculated molecular weight for this ACLY protein is 45.5 kDa. This ACLY protein is produced using e.coli expression system. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of ACLY, making it easier to detect and purify the ACLY recombinant protein in the later stages of expression and purification.ATP-citrate synthase (ACLY) is an important metabolic enzyme involving lipid metabolism and cellular energy balance. In lipid metabolism, ACLY catalyzes the synthesis of acetyl-coenzyme A and citrate within the cell, critical steps in cholesterol synthesis and fatty acid biogenesis. In recent years, researchers have observed overexpression of ACLY in various cancers, particularly malignant tumors like breast cancer. This suggests its significant role in the onset and progression of cancer. One of the most important areas of research is exploring the mechanisms of ACLY in cancer metabolic reprogramming and its potential application as a drug target. What’s more, ACLY is involved in regulating lipid-activated receptors and is associated with metabolic disorders such as diabetes.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[34370],"class_list":["post-109798","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-acly","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n