This POLR2A protein is a semi-custom product. There are 5 expression system options: Yeast, E. coli, In Vivo Biotinylation in E. coli, Baculovirus, and Mammalian cell. Your requirements will be given top priority in determining the protein tags. For proteins within 800 aa, risk-free custom service is guaranteed. It means you will not be charged if the protein cannot be delivered.
\nPOLR2A encodes the largest subunit of RNA polymerase II that transcribes DNA into RNA. POLR2A regulates various biological processes, including transcription, cell cycle progression, and chromatin remodeling [1] [2] [3]. Mutations in POLR2A have been linked to specific types of tumors. Recurrent somatic POLR2A mutations have been identified in meningiomas [4]. POLR2A also promotes the proliferation of cancer cells such as in gastric cancer, by advancing cell cycle progression [5].
\nFurthermore, POLR2A has been found to interact with other proteins such as CREB1, to regulate transcription and cellular processes like osteoclastic bone resorption [6]. Studies have also shown that POLR2A positively regulates histone modifications such as H3K4me3, suggesting its role in establishing chromatin conformation and gene expression patterns [2]. Moreover, variations in the length of certain genetic markers, like the poly-T variant in SCAF4, can influence the binding of POLR2A and impact the transcription of nearby genes, potentially contributing to disease processes like amyotrophic lateral sclerosis [7].
\nReferences:[1] Y. Li, Y. Liu, H. Xu, G. Jiang, K. Jeught, Y. Fanget al., Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of rna polymerase ii, Nature Communications, vol. 9, no. 1, 2018. https:\/\/doi.org\/10.1038\/s41467-018-06811-z[2] H. Yang, Z. Ma, P. Lin, C. Kuhn, M. Rahmeh, S. Mahneret al., Comparison of histone h3k4me3 between ivf and icsi technologies and between boy and girl offspring, International Journal of Molecular Sciences, vol. 22, no. 16, p. 8574, 2021. https:\/\/doi.org\/10.3390\/ijms22168574[3] Y. Chai, F. Tan, S. Ye, F. Liu, & Q. Fan, Identification of core genes and prediction of mirnas associated with osteoporosis using a bioinformatics approach, Oncology Letters, 2018. https:\/\/doi.org\/10.3892\/ol.2018.9508[4] V. Clark, A. Harmanc?, H. Bai, M. Youngblood, T. Lee, J. Baranoskiet al., Recurrent somatic mutations in polr2a define a distinct subset of meningiomas, Nature Genetics, vol. 48, no. 10, p. 1253-1259, 2016. https:\/\/doi.org\/10.1038\/ng.3651[5] Q. Jiang, J. Zhang, F. Li, X. Ma, F. Wu, J. Miaoet al., Polr2a promotes the proliferation of gastric cancer cells by advancing the overall cell cycle progression, Frontiers in Genetics, vol. 12, 2021. https:\/\/doi.org\/10.3389\/fgene.2021.688575[6] C. Liu, Y. Han, X. Zhao, B. Li, L. Xu, D. Liet al., polr2a blocks osteoclastic bone resorption and protects against osteoporosis by interacting with creb1, Journal of Cellular Physiology, vol. 236, no. 7, p. 5134-5146, 2021. https:\/\/doi.org\/10.1002\/jcp.30220[7] F. Theunissen, L. Flynn, R. Anderton, & P. Akkari, Short structural variants as informative genetic markers for als disease risk and progression, BMC Medicine, vol. 20, no. 1, 2022. https:\/\/doi.org\/10.1186\/s12916-021-02206-y<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[435],"class_list":["post-131115","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-polr2a","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n