Ciliogenesis And Planar Polarity Effector 2 (CPLANE2) Reagents

Ciliogenesis and planar polarity effector 2

Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.

Cytoplasm, cytoskeleton, cilium basal body.

Small GTPase superfamily, Rab family

CPLANE2; C1orf89; RSG1Ciliogenesis and planar polarity effector 2; REM2- and Rab-like small GTPase 1

Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular protein localization; cilium assembly; and regulation of vesicle-mediated transport. Predicted to be located in ciliary basal body.