Lysosomal Membrane Ascorbate-Dependent Ferrireductase Cyb561A3 (CYB561A3) Reagents

Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most problably involved in endosomal and lysosomal cellular iron homeostasis.

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

CYB561A3; CYBASC3; PSEC0259; Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3; Cytochrome b ascorbate-dependent protein 3; Cytochrome b561 family member A3; Lysosomal cytochrome b; LCytb