Btb/Poz Domain-Containing Adapter For Cul3-Mediated Rhoa Degradation Protein 1 (KCTD13) Reagents

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission.

The gene represented in this entry may act as a disease modifier for autism and schizophrenia associated with recurrent deletions and duplications of chromosome 16p11.2 region (PubMed:22596160, PubMed:25695269).

Nucleus.

BACURD family

Expressed in a wide variety of tissues.

BACD1_HUMAN; BACURD1; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; BTB/POZ domain-containing protein KCTD13; FKSG86; hBACURD1; KCTD13; PDIP1; POLDIP 1; POLDIP1; Polymerase delta-interacting protein 1; Potassium channel tetramerisation domain containing 13; PP6832; TNFAIP1 like polymerase delta interacting protein 1; TNFAIP1-like protein