Amino acids 500-946 form the expressed segment for recombinant Human WRN. This WRN protein is theoretically predicted to have a molecular weight of 58.3 kDa. Expression of this WRN protein is conducted in e.coli. The WRN gene fragment has been modified by fusing the N-terminal 10xHis tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant WRN protein during the following stages.The human bifunctional 3′-5′ exonuclease\/ATP-dependent helicase WRN is a crucial protein involved in DNA metabolism and repair. It plays a central role in maintaining genome stability by participating in various DNA repair pathways, including base excision repair and double-strand break repair. Additionally, WRN is implicated in telomere maintenance, ensuring the integrity of chromosome ends. Mutations in the WRN gene are associated with Werner syndrome, a rare premature aging disorder. Ongoing research on WRN aims to elucidate its precise functions, unravel its intricate role in cellular processes, and explore potential therapeutic strategies for conditions related to DNA damage and aging.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[52147],"class_list":["post-109282","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-wrn","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n