The recombinant Human CHRNA3 was expressed with the amino acid range of 32-240. The theoretical molecular weight of the CHRNA3 protein is 44.6 kDa. Expression of this CHRNA3 protein is conducted in e.coli. The CHRNA3 gene fragment has been modified by fusing the N-terminal 10xHis-SUMO tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant CHRNA3 protein during the following stages.The human neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) plays a pivotal role in neurotransmission as a component of the nicotinic acetylcholine receptor (nAChR). Activation of nAChRs, including CHRNA3, by acetylcholine or nicotine leads to the influx of ions, particularly sodium and calcium, causing membrane depolarization. This activity is fundamental for synaptic transmission, synaptic plasticity, and various cognitive functions within the central nervous system. Research areas involving CHRNA3 are diverse and include studies related to neurobiology, addiction, and neurodegenerative diseases. Furthermore, genetic variations in CHRNA3 have been associated with nicotine dependence and lung cancer susceptibility, making it a significant target in both neurological and pathological research.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[43475],"class_list":["post-109625","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-chrna3","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n