The recombinant human neurofilament light polypeptide (NEFL) is prepared in the E.coli. Its expression region lies in the fragment encoding amino acid residues 2-543 of the human NEFL protein. This recombinant human NEFL protein is labeled with a 10xHis-SUMO-tag at the N-terminus and a Myc-tag at the C-terminus. It harbors the full length of the mature protein in length. The purity of this NEFL protein is greater than 90% determined by SDS-PAGE. On the gel, this protein migrated to the band with a molecular weight of about 90 kDa. And its component has been identified by the LC-MS\/MS Analysis.
\nThe NEFL protein is the light chain of neurofilaments that play an important role in axonal growth and the determination of axonal caliber. As axons are injured and die in neurodegenerative processes, NEFL leaks into the interstitial space, then into CSF and plasma. NEFL levels thus increase as neurodegenerative diseases progress and can reflect disease activity. Numerous studies have shown that NEFL is a potential biomarker for determining the stage of disease, tracking progression, and aiding in the identification of disease-modifying treatments in neurological disorders.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[22469],"class_list":["post-109772","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-nefl","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n