The recombinant Human RRM1 was expressed with the amino acid range of 1-792. This RRM1 protein is expected to have a theoretical molecular weight of 92.1 kDa. The RRM1 protein was expressed in yeast. The RRM1 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant RRM1 protein during the following stages.The human ribonucleoside-diphosphate reductase large subunit (RRM1) is a key component of the ribonucleotide reductase enzyme complex. RRM1 plays a crucial role in DNA synthesis by catalyzing the conversion of ribonucleotides to deoxyribonucleotides, essential building blocks for DNA replication and repair. RRM1, along with the small subunit RRM2, contributes to the reduction of ribonucleotides to deoxyribonucleotides, a critical step in DNA synthesis. The activity of ribonucleotide reductase is tightly regulated to ensure proper control of DNA synthesis during the cell cycle. Altered expression of RRM1 has been observed in various cancers. Its overexpression is associated with resistance to certain chemotherapeutic agents, making it a potential target for cancer therapy. Research on RRM1 focuses on understanding its role in DNA metabolism, cell cycle regulation, and its implications in cancer development and treatment.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[37132],"class_list":["post-111200","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-rrm1","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n