Ankyrin Repeat And Socs Box Protein 4 (ASB4) Reagents

Ankyrin repeat and SOCS box protein 4

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism.

Ankyrin SOCS box (ASB) family

Ankyrin repeat and SOCS box containing 4; Ankyrin repeat and SOCS box containing protein 4 ; Ankyrin repeat and SOCS box protein 4; ASB 4; ASB-4; ASB4; ASB4_HUMAN

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.