The recombinant Human COMT was expressed with the amino acid range of 52-271. This COMT protein is theoretically predicted to have a molecular weight of 28.3 kDa. This protein is generated in a e.coli-based system. The COMT gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant COMT protein during the following stages.The human catechol O-methyltransferase (COMT) is a crucial enzyme involved in the metabolism of catecholamines, including dopamine, norepinephrine, and epinephrine. Its primary function is the methylation of catechol groups, playing a vital role in regulating neurotransmitter levels in the brain. The COMT gene exhibits polymorphisms, influencing enzyme activity and impacting cognitive and emotional processes. Research on COMT extends to neuropsychiatric disorders such as schizophrenia, bipolar disorder, and mood disorders, exploring associations between genetic variations and susceptibility to these conditions. Additionally, COMT inhibitors are investigated as potential therapeutics, contributing to advancements in neuropharmacology and personalized medicine. Understanding the multifaceted functions of COMT provides valuable insights into neurotransmitter regulation and its implications for mental health and therapeutic interventions.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[56645],"class_list":["post-109696","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-comt","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n