The region for expressing recombinant Human GFRAL contains amino acids 19-351. This GFRAL protein is theoretically predicted to have a molecular weight of 53.8 kDa. Expression of this GFRAL protein is conducted in e.coli. Fusion of the N-terminal 6xHis-SUMO tag into the GFRAL encoding gene fragment was conducted, allowing for easier detection and purification of the GFRAL protein in subsequent stages.Human GDNF family receptor alpha-like (GFRAL) is a receptor associated with energy homeostasis. GFRAL mainly functions to mediate the effects of the GDNF family ligands on appetite regulation and body weight. Investigating GFRAL provides insights into neuroendocrine signaling, metabolic disorders, and cancer-related wasting, offering potential applications in developing interventions for obesity, metabolic diseases, and cancer-associated cachexia. In metabolic research, GFRAL is crucial for understanding mechanisms underlying obesity and metabolic disorders. Targeting GFRAL presents a potential avenue for developing anti-obesity therapeutics. Additionally, GFRAL’s role in cancer cachexia implicates it in cancer research.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[30357],"class_list":["post-109795","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-gfral","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n