Double C2-Like Domain-Containing Protein Alpha (DOC2A) Reagents

Double C2-like domain-containing protein alpha

Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.

Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome.

Predominantly expressed in brain. Also expressed in testis.

DOC2ADouble C2-like domain-containing protein alpha; Doc2; Doc2-alpha