Amino acids 1-389 constitute the expression domain of recombinant Human RRM2. The calculated molecular weight for this RRM2 protein is 60.9 kDa. The RRM2 protein was expressed in e.coli. The RRM2 coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant RRM2 protein in following stages of expression and purification.The human ribonucleoside-diphosphate reductase subunit M2 (RRM2) is a critical enzyme involved in DNA synthesis and repair. As the small subunit of ribonucleotide reductase, RRM2 plays a key role in catalyzing the conversion of ribonucleotides to deoxyribonucleotides, which are essential building blocks for DNA replication. This process is crucial for cell proliferation and the maintenance of genomic integrity. RRM2 is tightly regulated throughout the cell cycle, ensuring the availability of deoxyribonucleotides during the DNA synthesis phases. Dysregulation of RRM2 has been implicated in various cancers, making it a potential target for anticancer therapies. Research on RRM2 spans areas such as cancer biology, cell cycle regulation, and nucleotide metabolism, contributing to the understanding of its functions and its potential as a therapeutic target in cancer treatment.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[69821],"class_list":["post-111351","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-rrm2","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n