This KAT7 protein is a semi-custom product. There are 5 expression system options: Yeast, E. coli, In Vivo Biotinylation in E. coli, Baculovirus, and Mammalian cell. Your requirements will be given top priority in determining the protein tags. For proteins within 800 aa, risk-free custom service is guaranteed. It means you will not be charged if the protein cannot be delivered.
\nKAT7 (HBO1 or MYST2) is a lysine acetyltransferase belonging to the MYST family of histone acetyltransferases. KAT7 is crucial in various biological processes such as DNA replication, gene transcription, and embryonic development [1] [2]. KAT7 catalyzes the acetylation of histones H4 and H3K14, contributing to pre-replication complex formation, DNA replication, and cell proliferation [1][2][3][4]. It has been shown to regulate chromatin structure, affecting the transcriptional activity of genes like vascular endothelial growth factor receptor 2 (VEGFR-2) [5]. KAT7 promotes radioresistance in breast cancer by upregulating PI3K\/AKT signaling [6]. Studies have also highlighted that KAT7 interacts with other proteins like BRPF3, emphasizing its role in specific enzymatic complexes [7]. Furthermore, KAT7 has been associated with various conditions such as diapause in bees [8], myocardial ischemia\/reperfusion injury [9], and laryngeal squamous cell carcinoma [10].
\nReferences:[1] S. Fan, J. Xing, Z. Jiang, Z. Zhang, H. Zhang, D. Wanget al., Effects of long non-coding rnas induced by the gut microbiome on regulating the development of colorectal cancer, Cancers, vol. 14, no. 23, p. 5813, 2022. https:\/\/doi.org\/10.3390\/cancers14235813[2] T. Pratamawati and I. Alwi, Summary of known genetic and epigenetic modification contributed to hypertension, International Journal of Hypertension, vol. 2023, p. 1-11, 2023. https:\/\/doi.org\/10.1155\/2023\/5872362[3] C. Zhang, Hbo1 determines smad action in pluripotency and mesendoderm specification, Nucleic Acids Research, vol. 52, no. 9, p. 4935-4949, 2024. https:\/\/doi.org\/10.1093\/nar\/gkae158[4] Y. Liang, Y. Su, C. Xu, N. Zhang, D. Liu, G. Liet al., Protein kinase d1 phosphorylation of kat7 enhances its protein stability and promotes replication licensing and cell proliferation, Cell Death Discovery, vol. 6, no. 1, 2020. https:\/\/doi.org\/10.1038\/s41420-020-00323-w[5] C. Xia, T. Yu, M. Li, T. Che, & J. Qu, Protein acetylation and deacetylation: an important regulatory modification in gene transcription (review), Experimental and Therapeutic Medicine, 2020. https:\/\/doi.org\/10.3892\/etm.2020.9073[6] Y. Ma, X. Chen, T. Ding, H. Zhang, Q. Zhang, H. Daiet al., Kat7 promotes radioresistance through upregulating pi3k\/akt signaling in breast cancer,, 2022. https:\/\/doi.org\/10.21203\/rs.3.rs-1477649\/v1[7] Y. Kou, L. You, C. Degerny, M. Ghorbani, X. Liu, L. Chenet al., The chromatin regulator brpf3 preferentially activates the hbo1 acetyltransferase but is dispensable for mouse development and survival, Journal of Biological Chemistry, vol. 291, no. 6, p. 2647-2663, 2016. https:\/\/doi.org\/10.1074\/jbc.m115.703041[8] P. Santos, N. Araujo, E. Fran?oso, A. Zuntini, & M. Arias, Diapause in a tropical oil-collecting bee: molecular basis unveiled by rna-seq, BMC Genomics, vol. 19, no. 1, 2018. https:\/\/doi.org\/10.1186\/s12864-018-4694-x[9] G. Sun, J. Shen, X. Wei, & G. Qi, Circular rna foxo3 relieves myocardial ischemia\/reperfusion injury by suppressing autophagy via inhibiting hmgb1 by repressing kat7 in myocardial infarction, Journal of Inflammation Research, vol. Volume 14, p. 6397-6407, 2021. https:\/\/doi.org\/10.2147\/jir.s339133[10] J. Li, Igf2bp2-m6a-circmmp9 axis recruits ets1 to promote trim59 transcription in laryngeal squamous cell carcinoma, Scientific Reports, vol. 14, no. 1, 2024. https:\/\/doi.org\/10.1038\/s41598-024-53422-4<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[168834,18],"product_tag":[60495],"class_list":["post-128083","product","type-product","status-publish","product_cat-proteins","product_cat-recombinant-proteins","product_tag-kat7","first","instock","shipping-taxable","product-type-simple"],"acf":[],"yoast_head":"\n