Rabbit anti-Human TP53RK Polyclonal Antibody

The antibody against TP53RK was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human TP53RK (NP_291028.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11404A

Number

Cat.No	ADA-11404A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TP53RK
Target Synonyms	PRPK; BUD32; TPRKB; GAMOS4; Nori-2; Nori-2p; dJ101A2; C20orf64; TP53RK	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, BxPC-3, HT-29, Jurkat, Mouse thymus, Rat testis	Application	ELISA, WB

Cat.No

ADA-11404A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TP53RK

Target Synonyms

PRPK; BUD32; TPRKB; GAMOS4; Nori-2; Nori-2p; dJ101A2; C20orf64; TP53RK

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, BxPC-3, HT-29, Jurkat, Mouse thymus, Rat testis

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human TP53RK (NP_291028.3).	Target Species	Human
Uniprot ID	Q96S44	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human TP53RK (NP_291028.3).

Target Species

Human

Uniprot ID

Q96S44

Immunogen Sequence

Background Information

Uniprot Id

Q96S44
Target Species

Human
Target Name

TP53RK
Target Full Name

EKC/KEOPS complex subunit TP53RK
Target Function

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

Protein kinase superfamily, BUD32 family
Target Tissue Specificity

Highly expressed in testis. Weakly expressed in heart kidney and spleen.
Target Synonyms

TP53RK; C20orf64; PRPKEKC/KEOPS complex subunit TP53RK; EC 3.6.-.-; Atypical serine/threonine protein kinase TP53RK; Nori-2; TP53-regulating kinase; EC 2.7.11.1; p53-related protein kinase
Target Background

Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4.

Rabbit anti-Human TP53RK Polyclonal Antibody

Specifications

Immunogen Information

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