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The antibody against HSD17B1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against HSD17B1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-12436A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HSD17B1 |
| Target Synonyms | E2DH; HSD17; EDHB17; EDH17B2; SDR28C1; 17-beta-HSD; 20-alpha-HSD; HSD17B1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat ovary, U-87MG | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P14061 | Immunogen Sequence |
Uniprot Id
P14061
Target Species
Human
Target Name
HSD17B1
Target Full Name
17-beta-hydroxysteroid dehydrogenase type 1
Target Function
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Also has 20-alpha-HSD activity. Uses preferentially NADH.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Target Research Area
Cancer
Target Synonyms
17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; DHB1_HUMAN; E17KSR; E2DH; EDH17B1; EDH17B2; EDHB17; Estradiol 17 beta dehydrogenase 1; Estradiol 17-beta-dehydrogenase 1; HSD17; HSD17B1; Hydroxysteroid (17 beta) dehydrogenase 1; MGC13814; Placental 17 beta hydroxysteroid dehydrogenase; Placental 17-beta-hydroxysteroid dehydrogenase; SDR28C1; Short chain dehydrogenase/reductase family 28CE,member 1
Target Background
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants.
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