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| Cat.No | ACP00330 | Target Name | RASGRP3 |
|---|---|---|---|
| Target Synonyms | Calcium and DAG-regulated guanine nucleotide exchange factor III;Guanine nucleotide exchange factor for Rap1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-690aa |
| Mol Weight | 85.2 kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IV61 |
|---|
Uniprot Id
Q8IV61
Target Species
Human
Target Name
RASGRP3
Target Full Name
Ras guanyl-releasing protein 3
Target Function
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
Target Protein Families
RASGRP family
Target Research Area
Signal Transduction
Target Synonyms
Calcium and DAG-regulated guanine nucleotide exchange factor III; Grp3; GRP3_HUMAN; Guanine nucleotide exchange factor for Rap1; Kiaa0846; RAS guanyl releasing protein 3 (calcium and DAG regulated); RAS guanyl releasing protein 3 calcium and DAG regualated guanine nucleotide exchange factor iii; Ras guanyl-releasing protein 3; RASGRP3
Target Background
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers.
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