Recombinant Human Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1), Truncated

Uniprot Id

O60243

Target Species

Human

Target Name

HS6ST1

Target Full Name

Heparan-sulfate 6-O-sulfotransferase 1

Target Function

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid.

Target Involvement

Hypogonadotropic hypogonadism 15 with or without anosmia (HH15)

Target Subcellular Location

Membrane; Single-pass type II membrane protein.

Target Protein Families

Sulfotransferase 6 family

Target Tissue Specificity

Expressed in fetal brain.

Target Research Area

Neuroscience

Target Synonyms

HS6ST1; HS6ST; Heparan-sulfate 6-O-sulfotransferase 1; HS6ST-1

Target Background

The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene.