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Amino acids 1-232 constitute the expression domain of recombinant Human IFI30. This IFI30 protein is theoretically predicted to have a molecular weight of 27.4 kDa. This IFI30 recombinant protein is manufactured in mammalian cell. The IFI30 coding gene included the C-terminal 10xHis tag, which simplifies the detection and purification processes of the recombinant IFI30 protein in following stages of expression and purification.Gamma-interferon-inducible lysosomal thiol reductase (IFI30) plays a crucial role in antigen processing within lysosomal compartments. It is induced by gamma-interferon and is primarily expressed in antigen-presenting cells, such as dendritic cells, macrophages, and B cells. IFI30 contributes to the degradation of protein antigens by reducing disulfide bonds, thereby facilitating their unfolding and subsequent processing for presentation on major histocompatibility complex class II (MHC-II) molecules. This process is vital for the activation of CD4+ T cells and the adaptive immune response. IFI30's involvement in antigen processing highlights its significance in immune surveillance and the body's defense against infections and diseases.
Amino acids 1-232 constitute the expression domain of recombinant Human IFI30. This IFI30 protein is theoretically predicted to have a molecular weight of 27.4 kDa. This IFI30 recombinant protein is manufactured in mammalian cell. The IFI30 coding gene included the C-terminal 10xHis tag, which simplifies the detection and purification processes of the recombinant IFI30 protein in following stages of expression and purification.Gamma-interferon-inducible lysosomal thiol reductase (IFI30) plays a crucial role in antigen processing within lysosomal compartments. It is induced by gamma-interferon and is primarily expressed in antigen-presenting cells, such as dendritic cells, macrophages, and B cells. IFI30 contributes to the degradation of protein antigens by reducing disulfide bonds, thereby facilitating their unfolding and subsequent processing for presentation on major histocompatibility complex class II (MHC-II) molecules. This process is vital for the activation of CD4+ T cells and the adaptive immune response. IFI30’s involvement in antigen processing highlights its significance in immune surveillance and the body’s defense against infections and diseases.
| Cat.No | ACP00932 | Target Name | IFI30 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Mammalian cell |
| Expression Range | 1-232aa | Mol Weight | 27.4 kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P13284 |
|---|
Uniprot Id
P13284
Target Species
Human
Target Name
IFI30
Target Full Name
Gamma-interferon-inducible lysosomal thiol reductase
Target Function
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.
Target Subcellular Location
Secreted. Lysosome.
Target Protein Families
GILT family
Target Research Area
Immunology
Target Synonyms
Gamma interferon inducible lysosomal thiol reductase; Gamma interferon inducible protein IP 30 ; Gamma-interferon-inducible lysosomal thiol reductase; Gamma-interferon-inducible protein IP-30; GILT ; GILT_HUMAN; IFI 30; IFI30; interferon gamma inducible protein 30; Interferon gamma inducible protein 30 preproprotein ; IP30 ; Legumaturain; Lysosomal thiol reductase; Lysosomal thiol reductase; gamma-interferon-inducible
Target Background
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.
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