Recombinant Human DNA repair protein RAD50 (RAD50), Truncated

Cat.No	ACP01389	Target Name	RAD50
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-235aa	Mol Weight	34.1 kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01389

Target Name

RAD50

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-235aa

Mol Weight

34.1 kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q92878

Background Information

Uniprot Id

Q92878
Target Species

Human
Target Name

RAD50
Target Full Name

DNA repair protein RAD50
Target Function

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Target Involvement

Nijmegen breakage syndrome-like disorder (NBSLD)
Target Subcellular Location

Nucleus. Chromosome, telomere. Chromosome.
Target Protein Families

SMC family, RAD50 subfamily
Target Tissue Specificity

Expressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

DNA repair protein RAD50; hRAD50; hsRAD50; Mrell; NBSLD; Rad 50; RAD50 2; rad50; RAD50 homolog (S cerevisiae); RAD50 homolog; RAD50 PEN; RAD50, S. cerevisiae, homolog of; RAD50_HUMAN; RAD502; Rad50l; Truncated RAD50 protein
Target Background

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Recombinant Human DNA repair protein RAD50 (RAD50), Truncated

Specifications

Immunogen Information

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