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The expression region of this recombinant Human MINPP1 covers amino acids 31-487. The calculated molecular weight for this MINPP1 protein is 54.1 kDa. The MINPP1 protein was expressed in yeast. The MINPP1 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant MINPP1 protein during the following stages.Human multiple inositol polyphosphate phosphatase 1 (MINPP1) is a phosphatase enzyme that catalyzes the dephosphorylation of inositol polyphosphates, specifically targeting inositol hexakisphosphate (InsP6) and inositol pentakisphosphate (InsP5). MINPP1 is involved in the homeostasis of inositol polyphosphates, which are signaling molecules implicated in various cellular processes, including cell growth, vesicle trafficking, and ion channel regulation. Dysregulation of inositol polyphosphate metabolism, including alterations in MINPP1 activity, has been associated with certain diseases, including cancer and neurodegenerative disorders. Research on MINPP1 contributes to the understanding of inositol signaling pathways and their impact on cellular physiology.
The expression region of this recombinant Human MINPP1 covers amino acids 31-487. The calculated molecular weight for this MINPP1 protein is 54.1 kDa. The MINPP1 protein was expressed in yeast. The MINPP1 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant MINPP1 protein during the following stages.Human multiple inositol polyphosphate phosphatase 1 (MINPP1) is a phosphatase enzyme that catalyzes the dephosphorylation of inositol polyphosphates, specifically targeting inositol hexakisphosphate (InsP6) and inositol pentakisphosphate (InsP5). MINPP1 is involved in the homeostasis of inositol polyphosphates, which are signaling molecules implicated in various cellular processes, including cell growth, vesicle trafficking, and ion channel regulation. Dysregulation of inositol polyphosphate metabolism, including alterations in MINPP1 activity, has been associated with certain diseases, including cancer and neurodegenerative disorders. Research on MINPP1 contributes to the understanding of inositol signaling pathways and their impact on cellular physiology.
| Cat.No | ACP02458 | Target Name | MINPP1 |
|---|---|---|---|
| Target Synonyms | 1; Multiple inositol polyphosphate phosphatase 1; multiple inositol polyphosphate phosphatase 2, 3, 3; 4; 5)-tetrakisphosphate 3-phosphatase; 5)P(4) 3-phosphatase; DKFZp564L2016; HIPER1; Inositol (1; inositol (1, 4, 5)-tetrakisphosphate 3-phosphatase; Ins(1; ins(1, 5)P(4) 3-phosphatase; MINP1_HUMAN; Minpp1; MINPP2; MIPP; Multiple inositol polyphosphate histidine phosphatase | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 31-487aa |
| Mol Weight | 54.1kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UNW1 |
|---|
Uniprot Id
Q9UNW1
Target Species
Human
Target Name
MINPP1
Target Full Name
Multiple inositol polyphosphate phosphatase 1
Target Function
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy.
Target Involvement
Thyroid cancer, non-medullary, 2 (NMTC2)
Target Subcellular Location
Endoplasmic reticulum lumen.
Target Protein Families
Histidine acid phosphatase family, MINPP1 subfamily
Target Tissue Specificity
Widely expressed with highest levels in kidney, liver and placenta.
Target Research Area
Signal Transduction
Target Synonyms
3; 4; 5)-tetrakisphosphate 3-phosphatase; 5)P(4) 3-phosphatase; DKFZp564L2016; HIPER1; Inositol (1; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1; ins(1,3,4,5)P(4) 3-phosphatase; MINP1_HUMAN; Minpp1; MINPP2; MIPP; Multiple inositol polyphosphate histidine phosphatase, 1; Multiple inositol polyphosphate phosphatase 1; multiple inositol polyphosphate phosphatase 2
Target Background
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2, 3 bisphosphoglycerate (2, 3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2, 3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.
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