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In e.coli cells, the generation of recombinant Human VEGFC protein involves cloning a DNA fragment encoding the Human VEGFC protein (112-227aa) into a plasmid vector, which is then transferred into the e.coli cells. Positive cells are selected, cultured, and induced to express the VEGFC protein. A N-terminal GST tag is attached to the protein. Lysis of the cells allows for the harvest of the recombinant Human VEGFC protein. The collected recombiant Human VEGFC protein is subjected to affinity purification and is identified using SDS-PAGE and subsequent staining of the gel with Coomassie Brilliant Blue. Its purity is greater than 90%.
In e.coli cells, the generation of recombinant Human VEGFC protein involves cloning a DNA fragment encoding the Human VEGFC protein (112-227aa) into a plasmid vector, which is then transferred into the e.coli cells. Positive cells are selected, cultured, and induced to express the VEGFC protein. A N-terminal GST tag is attached to the protein. Lysis of the cells allows for the harvest of the recombinant Human VEGFC protein. The collected recombiant Human VEGFC protein is subjected to affinity purification and is identified using SDS-PAGE and subsequent staining of the gel with Coomassie Brilliant Blue. Its purity is greater than 90%.
| Cat.No | ACP02910 | Target Name | VEGFC |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 112-227aa | Mol Weight | 40.1kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P49767 |
|---|
Uniprot Id
P49767
Target Species
Human
Target Name
VEGFC
Target Full Name
Vascular endothelial growth factor C
Target Function
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
Target Involvement
Lymphedema, hereditary, 1D (LMPH1D)
Target Subcellular Location
Secreted.
Target Protein Families
PDGF/VEGF growth factor family
Target Tissue Specificity
Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.
Target Research Area
Cancer
Target Synonyms
Flt 4L; Flt4 ligand; FLT4 ligand DHM; Flt4-L; Flt4L; Vascular endothelial growth factor C; Vascular endothelial growth factor related protein; Vascular endothelial growth factor-related protein; VEGF C; VEGF-C; Vegfc; VEGFC_HUMAN; VRP
Target Background
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors.
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