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Explore the complexities of epigenetics and nuclear signaling with our high-quality Recombinant Human SIRT6 protein. This NAD-dependent protein deacylase sirtuin-6 is expressed in an E. coli system, ensuring a consistently reliable and efficient product for your research applications. The full-length mature protein (2-355aa) is designed to deliver accurate and reproducible results in various experimental settings. The N-terminal GST-tag enables convenient protein purification and detection, while a purity of greater than 90% as determined by SDS-PAGE ensures optimal performance in your experiments. Our Recombinant Human SIRT6 protein is available in both liquid and lyophilized powder forms, catering to your specific research needs and facilitating breakthroughs in the ever-evolving field of epigenetics and nuclear signaling.
Explore the complexities of epigenetics and nuclear signaling with our high-quality Recombinant Human SIRT6 protein. This NAD-dependent protein deacylase sirtuin-6 is expressed in an E. coli system, ensuring a consistently reliable and efficient product for your research applications. The full-length mature protein (2-355aa) is designed to deliver accurate and reproducible results in various experimental settings.
The N-terminal GST-tag enables convenient protein purification and detection, while a purity of greater than 90% as determined by SDS-PAGE ensures optimal performance in your experiments. Our Recombinant Human SIRT6 protein is available in both liquid and lyophilized powder forms, catering to your specific research needs and facilitating breakthroughs in the ever-evolving field of epigenetics and nuclear signaling.
| Cat.No | ACP03238 | Target Name | SIRT6 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-355aa | Mol Weight | 66.0kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N6T7 |
|---|
Uniprot Id
Q8N6T7
Target Species
Human
Target Name
SIRT6
Target Full Name
NAD-dependent protein deacylase sirtuin-6
Target Function
NAD-dependent protein deacetylase involved in various processes including telomere maintenance and gene expression, and consequently has roles in genomic stability, cell senescence and apoptosis. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. May also be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for normal IGF1 serum levels and normal glucose homeostasis. Regulates the production of TNF protein. Has a role in the regulation of life span.
Target Subcellular Location
Nucleus, nucleoplasm. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.
Target Protein Families
Sirtuin family, Class IV subfamily
Target Synonyms
2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Regulatory protein SIR2 homolog; SIR2 like 6; SIR2 like protein 6 ; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIR6_HUMAN; SIRT 6; SIRT6; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) ; Sirtuin 6; Sirtuin type 6; Sirtuin6
Target Background
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms.
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