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This Human GPD1 recombinant protein was produced in E.coli, where the gene sequence encoding Human GPD1 (1-349aa) was expressed with the N-terminal 6xHis-SUMO tag. The purity of this GPD1 protein was greater than 90% by SDS-PAGE.GPD1 is an enzyme that catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate inside cells. This reaction is a critical step in the glycerolipid metabolism pathway. The enzyme plays a significant role in energy metabolism and fatty acid synthesis. The GPD1 protein is involved in regulating the synthesis of triglycerides, which is one way the body stores energy. It is also associated with glucose metabolism and insulin response, closely linked to the regulation of blood sugar levels. GPD1 protein is widely expressed in various tissues, including the liver, muscles, and adipose tissue. This reflects its different biological functions in different tissues. Some studies suggest that GPD1 is associated with metabolic diseases such as obesity and diabetes. Abnormal activity or expression levels of GPD1 may be related to the onset and development of these diseases.
This Human GPD1 recombinant protein was produced in E.coli, where the gene sequence encoding Human GPD1 (1-349aa) was expressed with the N-terminal 6xHis-SUMO tag. The purity of this GPD1 protein was greater than 90% by SDS-PAGE.GPD1 is an enzyme that catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate inside cells. This reaction is a critical step in the glycerolipid metabolism pathway. The enzyme plays a significant role in energy metabolism and fatty acid synthesis. The GPD1 protein is involved in regulating the synthesis of triglycerides, which is one way the body stores energy. It is also associated with glucose metabolism and insulin response, closely linked to the regulation of blood sugar levels. GPD1 protein is widely expressed in various tissues, including the liver, muscles, and adipose tissue. This reflects its different biological functions in different tissues. Some studies suggest that GPD1 is associated with metabolic diseases such as obesity and diabetes. Abnormal activity or expression levels of GPD1 may be related to the onset and development of these diseases.
| Cat.No | ACP04070 | Target Name | GPD1 |
|---|---|---|---|
| Target Synonyms | cytoplasmic; Glycerol-3-phosphate dehydrogenase 1 (soluble); Glycerol-3-phosphate dehydrogenase; Glycerol-3-phosphate dehydrogenase, soluble ; Glycerphosphate dehydrogenase; GPD-C; gpd1; Gpd1 protein; Gpd3; GPDA_HUMAN; Gpdc; GPDH; GPDH-C; Gpdhc; HTGTI; KIAA4010; MGC93453; MGPD; mKIAA4010 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-349aa |
| Mol Weight | 53.6kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P21695 |
|---|
Uniprot Id
P21695
Target Species
Human
Target Name
GPD1
Target Full Name
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Target Function
Has glycerol-3-phosphate dehydrogenase activity.
Target Involvement
Hypertriglyceridemia, transient infantile (HTGTI)
Target Subcellular Location
Cytoplasm.
Target Protein Families
NAD-dependent glycerol-3-phosphate dehydrogenase family
Target Tissue Specificity
Expressed in liver (at protein level).
Target Research Area
Signal Transduction
Target Synonyms
AI747587; cytoplasmic; EC 1.1.1.8; FLJ26652; G3PD; Gdc-1; Gdc1; Gdp1; Glycerol 3 phosphate dehydrogenase 1; Glycerol 3 phosphate dehydrogenase cytosolic; Glycerol 3 phosphate dehydrogenase soluble; Glycerol-3-phosphate dehydrogenase [NAD+]; Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic; Glycerol-3-phosphate dehydrogenase 1 (soluble); Glycerol-3-phosphate dehydrogenase; Glycerol-3-phosphate dehydrogenase, soluble ; Glycerphosphate dehydrogenase; GPD-C; gpd1; Gpd1 protein; Gpd3; GPDA_HUMAN; Gpdc; GPDH; GPDH-C; Gpdhc; HTGTI; KIAA4010; MGC93453; MGPD; mKIAA4010
Target Background
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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