Recombinant Human Amiloride-sensitive sodium channel subunit beta (SCNN1B), Truncated

Cat.No	ACP05503	Target Name	SCNN1B
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05503

Target Name

SCNN1B

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P51168

Background Information

Uniprot Id

P51168
Target Species

Human
Target Name

SCNN1B
Target Full Name

Epithelial sodium channel subunit beta
Target Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Target Involvement

Pseudohypoaldosteronism 1, autosomal recessive (PHA1B); Liddle syndrome (LIDLS); Bronchiectasis with or without elevated sweat chloride 1 (BESC1)
Target Subcellular Location

Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
Target Protein Families

Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1B subfamily
Target Tissue Specificity

Detected in placenta, lung and kidney. Expressed in kidney (at protein level).
Target Synonyms

Amiloride sensitive sodium channel subunit beta; Amiloride-sensitive sodium channel subunit beta; Beta NaCH; Beta-ENaC; Beta-NaCH; ENaC beta; ENaCB; Epithelial Na(+) channel subunit beta; Epithelial Na+ channel beta subunit; Epithelial Na+ channel subunit beta; Epithelial sodium channel beta 2 subunit; Epithelial sodium channel beta 3 subunit; Nonvoltage gated sodium channel 1 beta subunit; Nonvoltage gated sodium channel 1 subunit beta; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB; SCNN 1B; SCNN1B; SCNNB_HUMAN; Sodium channel nonvoltage gated 1 beta (Liddle syndrome); Sodium channel nonvoltage gated 1 beta
Target Background

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.

Recombinant Human Amiloride-sensitive sodium channel subunit beta (SCNN1B), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Amiloride-sensitive sodium channel subunit beta (SCNN1B), Truncated Now

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