Recombinant Human Solute carrier family 41 member 1 (SLC41A1), Truncated

Uniprot Id

Q8IVJ1

Target Species

Human

Target Name

SLC41A1

Target Full Name

Solute carrier family 41 member 1

Target Function

Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

SLC41A transporter family

Target Tissue Specificity

Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.

Target Synonyms

SLC41A1; Solute carrier family 41 member 1