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| Cat.No | ACP06100 | Target Name | ARFGEF3 |
|---|---|---|---|
| Target Synonyms | ARFGEF3; BIG3; C6orf92; KIAA1244; Brefeldin A-inhibited guanine nucleotide-exchange protein 3; ARFGEF family member 3 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5TH69 |
|---|
Uniprot Id
Q5TH69
Target Species
Human
Target Name
ARFGEF3
Target Full Name
Brefeldin A-inhibited guanine nucleotide-exchange protein 3
Target Function
Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells. Also regulates glucagon granule production in pancreatic alpha cells. Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells.
Target Subcellular Location
Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein.
Target Tissue Specificity
Expressed in breast cancer cell lines. Not expressed in normal tissues such as duct, mammary gland, lung, heart, liver, kidnay, bone marrow.
Target Synonyms
ARFGEF3; BIG3; C6orf92; KIAA1244; Brefeldin A-inhibited guanine nucleotide-exchange protein 3; ARFGEF family member 3
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