Recombinant Human Autophagy-related protein 9B (ATG9B), Truncated

Uniprot Id

Q674R7

Target Species

Human

Target Name

ATG9B

Target Full Name

Autophagy-related protein 9B

Target Function

Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. In addition to autophagy, also plays a role in necrotic cell death.

Target Subcellular Location

Preautophagosomal structure membrane; Multi-pass membrane protein.

Target Protein Families

ATG9 family

Target Tissue Specificity

Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.

Target Synonyms

APG9 like 2; APG9-like 2; Apg912; APG9L2; Apgdc2; ATG9 autophagy related 9 homolog B (S. cerevisiae); Atg9b; ATG9B_HUMAN; Autophagy 9 like 2 protein; Autophagy related protein 9B; Autophagy-related protein 9B; Endothelial nitric oxide synthase antisense; eONE; Gm574; Nitric oxide synthase 3 antisense; Nitric oxide synthase 3 overlapping antisense gene protein; Nitric oxide synthase 3-overlapping antisense gene protein; NOS3AS; Protein sONE; SONE

Target Background

This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants.