Recombinant Human Probable palmitoyltransferase ZDHHC21 (ZDHHC21), Truncated

Uniprot Id

Q8IVQ6

Target Species

Human

Target Name

ZDHHC21

Target Full Name

Palmitoyltransferase ZDHHC21

Target Function

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor. Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK

Target Subcellular Location

Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Target Protein Families

DHHC palmitoyltransferase family

Target Tissue Specificity

Widely expressed.

Target Synonyms

ZDHHC21; Palmitoyltransferase ZDHHC21; DHHC domain-containing cysteine-rich protein 21; DHHC-21; Zinc finger DHHC domain-containing protein 21