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| Cat.No | ACP08366 | Target Name | TRAM2 |
|---|---|---|---|
| Target Synonyms | TRAM2; KIAA0057; Translocating chain-associated membrane protein 2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q15035 |
|---|
Uniprot Id
Q15035
Target Species
Human
Target Name
TRAM2
Target Full Name
Translocating chain-associated membrane protein 2
Target Function
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
TRAM family
Target Synonyms
TRAM2; KIAA0057; Translocating chain-associated membrane protein 2
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