Recombinant human Protein HEXIM2

Uniprot Id

Q96MH2

Target Species

Human

Target Name

HEXIM2

Target Full Name

Protein HEXIM2

Target Function

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.

Target Subcellular Location

Nucleus.

Target Protein Families

HEXIM family

Target Tissue Specificity

Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.

Target Research Area

Transcription

Target Synonyms

Hexamethylene bis-acetamide-inducible protein 2; Hexamthylene bis-acetamide inducible 2 ; HEXI2_HUMAN; hexim 2; HEXIM2; L3; Protein HEXIM2

Target Background

This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants.