Recombinant Human Influenza virus NS1A-binding protein (IVNS1ABP)

Uniprot Id

Q9Y6Y0

Target Species

Human

Target Name

IVNS1ABP

Target Full Name

Influenza virus NS1A-binding protein

Target Function

Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm.

Target Synonyms

IVNS1ABP; ARA3; FLARA3; KIAA0850; KLHL39; NS1; NS1BP; HSPC068; Influenza virus NS1A-binding protein; NS1-BP; NS1-binding protein; Aryl hydrocarbon receptor-associated protein 3; Kelch-like protein 39

Target Background

Involved in RNA splicing; negative regulation of protein ubiquitination; and response to virus. Located in cytosol. Implicated in immunodeficiency 70.