Recombinant Human Phosphotidylinositol phosphatase PTPRQ (PTPRQ), Truncated

Uniprot Id

Q9UMZ3

Target Species

Human

Target Name

PTPRQ

Target Full Name

Phosphatidylinositol phosphatase PTPRQ

Target Function

Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells

Target Involvement

Deafness, autosomal recessive, 84A (DFNB84A); Deafness, autosomal dominant, 73 (DFNA73)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Protein-tyrosine phosphatase family, Receptor class 2A subfamily

Target Tissue Specificity

In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.

Target Synonyms

PTPRQ; Phosphatidylinositol phosphatase PTPRQ; EC 3.1.3.-; Receptor-type tyrosine-protein phosphatase Q; PTP-RQ; R-PTP-Q; EC 3.1.3.48