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| Cat.No | ACP11880 | Target Name | AGXT2 |
|---|---|---|---|
| Target Synonyms | ; R)-3-amino-2-methylpropionate--pyruvate transaminase; EC 2.6.1.40; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-AIBAT, AGXT2; AGT2Alanine--glyoxylate aminotransferase 2; mitochondrial; AGT 2; EC 2.6.1.44 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 42-514 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BYV1 |
|---|
Uniprot Id
Q9BYV1
Target Species
Human
Target Name
AGXT2
Target Full Name
Alanine--glyoxylate aminotransferase 2, mitochondrial
Target Function
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Target Subcellular Location
Mitochondrion.
Target Protein Families
Class-III pyridoxal-phosphate-dependent aminotransferase family
Target Synonyms
AGXT2; AGT2Alanine--glyoxylate aminotransferase 2; mitochondrial; AGT 2; EC 2.6.1.44,; R)-3-amino-2-methylpropionate--pyruvate transaminase; EC 2.6.1.40; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-AIBAT
Target Background
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants.
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