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| Cat.No | ACP12900 | Target Name | CHAMP1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96JM3 |
|---|
Uniprot Id
Q96JM3
Target Species
Human
Target Name
CHAMP1
Target Full Name
Chromosome alignment-maintaining phosphoprotein 1
Target Function
Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.
Target Involvement
Mental retardation, autosomal dominant 40 (MRD40)
Target Subcellular Location
Nucleus. Chromosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.
Target Synonyms
C13orf8; CAMP; CHAMP; CHAMP1; CHAP1_HUMAN; chromosome 13 open reading frame 8; Chromosome alignment-maintaining phosphoprotein 1; FLJ90413; KIAA1802; Zinc finger protein 828; Zinc finger protein KIAA1802; ZNF828
Target Background
This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability.
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