Recombinant Human Grainyhead-like protein 3 homolog (GRHL3)

Cat.No	ACP13612	Target Name	GRHL3
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-626	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP13612

Target Name

GRHL3

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-626

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8TE85

Background Information

Uniprot Id

Q8TE85
Target Species

Human
Target Name

GRHL3
Target Full Name

Grainyhead-like protein 3 homolog
Target Function

Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair. Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Also required for proper development of the oral periderm. No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity.
Target Involvement

Van der Woude syndrome 2 (VWS2)
Target Subcellular Location

Nucleus.
Target Protein Families

Grh/CP2 family, Grainyhead subfamily
Target Tissue Specificity

Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific.
Target Synonyms

Drosophila; Grainyhead like 3; Grainyhead like protein 3 homolog; Grainyhead-like protein 3 homolog; grhl3; GRHL3_HUMAN; Sister of mammalian grainyhead; Sister of mammalian grainyhead protein; SOM; TFCP2L4; Transcription factor CP2 like 4; Transcription factor CP2-like 4

Recombinant Human Grainyhead-like protein 3 homolog (GRHL3)

Specifications

Immunogen Information

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