Recombinant Human DNA repair and recombination protein RAD54-like (RAD54L)

Uniprot Id

Q92698

Target Species

Human

Target Name

RAD54L

Target Full Name

DNA repair and recombination protein RAD54-like

Target Function

Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA.

Target Subcellular Location

Nucleus.

Target Protein Families

SNF2/RAD54 helicase family

Target Synonyms

DNA repair and recombination protein RAD54 like ; DNA repair and recombination protein RAD54-like; hHR 54; hHR54; HR 54; HR54; hRAD 54; hRAD54; RAD 54A; RAD 54L; RAD54 (S. cerevisiae) like ; RAD54 homolog; RAD54 like (S. cerevisiae); RAD54 like; RAD54 like protein; RAD54_HUMAN; RAD54A; RAD54L

Target Background

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.