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Recombinant Human Nuclear receptor-binding factor 2 (NRBF2)

ACP14705

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Specifications

Cat.No	ACP14705	Target Name	NRBF2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-287	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q96F24

Background Information

Uniprot Id

Q96F24
Target Species

Human
Target Name

NRBF2
Target Full Name

Nuclear receptor-binding factor 2
Target Function

May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).; Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation.
Target Subcellular Location

Nucleus. Cytoplasm. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome.
Target Tissue Specificity

Detected in keratinocytes, liver and placenta. Expressed in a subset of cells in pediatric medulloblastoma.
Target Synonyms

Comodulator of PPAR and RXR 1; Comodulator of PPAR and RXR 2; Comodulator of PPAR and RXR; COPR; COPR1; COPR2; DKFZp564C1664; FLJ30395; NRBF 2 ; NRBF-2; NRBF2; NRBF2_HUMAN; Nuclear receptor binding factor 2; Nuclear receptor-binding factor 2
Target Background

Involved in autophagy. Located in cytoplasm. Colocalizes with phosphatidylinositol 3-kinase complex, class III.

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Recombinant Human Nuclear receptor-binding factor 2 (NRBF2)

Specifications

Immunogen Information

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