Recombinant Human Heparan sulfate glucosamine 3-O-sulfotransferase 5 (HS3ST5), Truncated

Uniprot Id

Q8IZT8

Target Species

Human

Target Name

HS3ST5

Target Full Name

Heparan sulfate glucosamine 3-O-sulfotransferase 5

Target Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry

Target Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Target Protein Families

Sulfotransferase 1 family

Target Tissue Specificity

Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon.

Target Synonyms

3-OST-5; 3OST5; h3-OST-5; Heparan sulfate (glucosamine) 3 O sulfotransferase 5; Heparan sulfate 3 OST 5; Heparan sulfate 3-O-sulfotransferase 5; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5; Heparan sulfate glucosamine 3 sulfotransferase 5; Heparan sulfate glucosamine 3-O-sulfotransferase 5; HS3OST5; HS3S5_HUMAN; HS3ST5; NBLA04021; Nbla04021 product like