Recombinant Human WD repeat and FYVE domain-containing protein 3 (WDFY3), Truncated

Uniprot Id

Q8IZQ1

Target Species

Human

Target Name

WDFY3

Target Full Name

WD repeat and FYVE domain-containing protein 3

Target Function

Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P).

Target Involvement

Microcephaly 18, primary, autosomal dominant (MCPH18)

Target Subcellular Location

Nucleus membrane. Cytoplasm, cytosol. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, axon.

Target Tissue Specificity

Expressed in osteoclast and their mononuclear precursors (at protein level).

Target Synonyms

WDFY3; KIAA0993; WD repeat and FYVE domain-containing protein 3; Autophagy-linked FYVE protein; Alfy