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Recombinant Human HORMA domain-containing protein 1 (HORMAD1)

ACP15264

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Specifications

Cat.No	ACP15264	Target Name	HORMAD1
Target Synonyms	HORMAD1; NOHMA; HORMA domain-containing protein 1; Cancer/testis antigen 46; CT46; Newborn ovary HORMA protein	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-394
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q86X24

Background Information

Uniprot Id

Q86X24
Target Species

Human
Target Name

HORMAD1
Target Full Name

HORMA domain-containing protein 1
Target Function

Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.
Target Subcellular Location

Nucleus. Chromosome.
Target Tissue Specificity

Testis-specific. Over-expressed in carcinomas.
Target Synonyms

HORMAD1; NOHMA; HORMA domain-containing protein 1; Cancer/testis antigen 46; CT46; Newborn ovary HORMA protein

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Recombinant Human HORMA domain-containing protein 1 (HORMAD1)

Specifications

Immunogen Information

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