Recombinant Human Ras-related protein Rab-43 (RAB43)

Uniprot Id

Q86YS6

Target Species

Human

Target Name

RAB43

Target Full Name

Ras-related protein Rab-43

Target Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Target Subcellular Location

Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network.

Target Protein Families

Small GTPase superfamily, Rab family

Target Tissue Specificity

Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.

Target Synonyms

RAB41; RAB43; RAB43_HUMAN; Ras related protein Rab 41 ; Ras related protein Rab 43; Ras-related protein Rab-41; Ras-related protein Rab-43