Recombinant Human Regulator of G-protein signaling 9-binding protein (RGS9BP), Truncated

Uniprot Id

Q6ZS82

Target Species

Human

Target Name

RGS9BP

Target Full Name

Regulator of G-protein signaling 9-binding protein

Target Function

Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation.

Target Involvement

Prolonged electroretinal response suppression (PERRS)

Target Subcellular Location

Membrane; Single-pass type IV membrane protein.

Target Protein Families

RGS7BP/RGS9BP family

Target Synonyms

RGS9BP; R9AP; Regulator of G-protein signaling 9-binding protein; RGS9-anchoring protein

Target Background

The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia.