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| Cat.No | ACP16415 | Target Name | ARHGEF18 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6ZSZ5 |
|---|
Uniprot Id
Q6ZSZ5
Target Species
Human
Target Name
ARHGEF18
Target Full Name
Rho guanine nucleotide exchange factor 18
Target Function
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells.
Target Involvement
Retinitis pigmentosa 78 (RP78)
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Apical cell membrane.
Target Tissue Specificity
Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils. Isoform 2: Expressed in eosinophils. Isoform 3: Expressed in eosinophils. Is
Target Synonyms
114 kDa Rho specific guanine nucleotide exchange factor; 114 kDa Rho-specific guanine nucleotide exchange factor; ARHGEF 18; Arhgef18; ARHGI_HUMAN; KIAA0521; MGC15913; p114 Rho GEF; p114-Rho-GEF; p114RhoGEF; Rho guanine nucleotide exchange factor 18; Rho specific guanine nucleotide exchange factor p114; Rho/Rac guanine nucleotide exchange factor (GEF) 18; Rho/Rac guanine nucleotide exchange factor 18; SA RhoGEF; SA-RhoGEF; Septin associated RhoGEF; Septin-associated RhoGEF
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