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| Cat.No | ACP17670 | Target Name | CLEC16A |
|---|---|---|---|
| Target Synonyms | CLEC16A; KIAA0350Protein CLEC16A; C-type lectin domain family 16 member A | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q2KHT3 |
|---|
Uniprot Id
Q2KHT3
Target Species
Human
Target Name
CLEC16A
Target Full Name
Protein CLEC16A
Target Function
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
Target Involvement
Diabetes mellitus, insulin-dependent (IDDM)
Target Subcellular Location
Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
Target Protein Families
CLEC16A/gop-1 family
Target Tissue Specificity
Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells.
Target Synonyms
CLEC16A; KIAA0350Protein CLEC16A; C-type lectin domain family 16 member A
Target Background
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene.
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