Recombinant Human Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J), Truncated

Uniprot Id

Q15735

Target Species

Human

Target Name

INPP5J

Target Full Name

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Target Function

Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Inositol 1,4,5-trisphosphate 5-phosphatase type II family

Target Synonyms

INPP5J; PIB5PA; PIPP; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; EC 3.1.3.56; Inositol polyphosphate 5-phosphatase J

Target Background

Predicted to enable phosphatidylinositol-3, 4, 5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4, 5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle.